Mesenchymal stromal cells extend life span in mice
The recent study published in Scientific Reports captured my attention, because of stem cells and aging connection. The authors aimed to transplant young mesenchymal stromal cells (MSC) into old...
View ArticleTransplantation of mesenchymal stromal cells for radioprotection
Mesenchymal stromal cells (MSC) form a niche for hematopoietic stem cells in bone marrow. Damaging effects of radiation on hematopoiesis also caused by niche cells alteration and formation of “toxic...
View ArticleTill & McCulloch Meetings 2012 – Reflections on Caplan’s view of mesenchymal...
Arnold Caplan is a scientist, who coined a term “mesenchymal stem cells” in 1991 for the type of bone marrow cells, previously known as “stromal stem cells”. This term became widely adopted. He gave a...
View ArticleStem Cell Autopsy – a collection of clinical cases
More than 2 years ago I’ve started to collect a clinical cases of pathology (autopsy/ biopsy), from the patients who underwent cell therapy procedures. Initially I intended to cover only “stem cell...
View ArticleImpact of fetal bovine serum on toxicity of mesenchymal stromal cell...
The recent SafeCell study, published in PLoS ONE, analyzed the safety profile of mesenchymal stromal cells (MSC), administered systemically in patients. I blogged about it here. One of the most...
View ArticleFailure of mesenchymal stem cells in GVHD – is devil in the cell prep?
As we all know, Phase III clinical trial, sponsored by Osiris Therapeutics and assessed efficacy of mesenchymal stem cells (MSC) (product “Prochymal”) for treatment of Graft-Versus-Host-Disease (GVHD)...
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Recommendations for assessment of genetic instability of mesenchymal stromal...
We’ve written a lot about assessment of tumorigenicity risk in mesenchymal stromal cell (MSC)-based products. Recently, recommendations of the Cell Products Working Party and the Committee for...
View ArticleMSC 2013: Considerations for MSCs infusion
MSC 2013 conference has finished this week in Cleveland. I was really enjoying the conference and I’d highly recommend to attend it to everyone, who is working in mesenchymal stem cell (MSC) field....
View ArticleCryopreservation of mesenchymal stromal cells can attenuate clinical immune...
As Jacques Galipeau reported in conferences and in the paper, cryopreservation could negatively affect therapeutic “immunomodulatory value” of mesenchymal stromal cells (MSC). There was no independent...
View ArticleHuman MSC extend life span in rats
The recent study, published in Stem Cells TM, demonstrates that infusions of mesenchymal stromal cells (MSC) can impact aging and longevity. A group of Korean researchers used human MSCs in rats to...
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